Abnormal eye movements in spinocerebellar ataxia type 3

Abstract Background Abnormal eye movements are common in spinocerebellar ataxias Type 3 (SCA3). We conducted the research to explore frequency of abnormal Chinese patients with SCA3, compare demographic and clinical characteristics between SCA3 without each type movement, correlation severity ataxia. Methods Seventy-four were enrolled this cross-sectional study. Six types including impaired smooth pursuit, increased square-wave jerks (SWJ), gaze-evoked nystagmus (GEN), slowing saccades, saccadic hypo/hypermetria supranuclear gaze palsy evaluated by experienced neurologists. The ataxia was Scale for Assessment Rating Ataxia (SARA). Results prevalence SWJ, GEN, 28.4, 13.5, 78.4, 41.9, 23.0, 5.4%, respectively. GEN had higher scores International Cooperative (ICARS-IV) total ICARS, longer length CAG repeat than GEN. saccades a disease duration, ICARS-I, ICARS-II, ICARS SARA saccades. ICARS-III, ICARS-IV, hypo/hypermetria. did not differ significantly or palsy. Multivariate linear regression showed that number (0–6), Hamilton Depression Scale-24 (HDRS-24) score, positively correlated whereas Montreal Cognitive (MoCA) score negatively SCA3. Conclusions An movement